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Does ischemic preconditioning occur in patients?
1Heart Institute Research Laboratory, Hospital of the Good Samaritan, University of Southern California, Los Angeles 90017.
Journal of the American College of Cardiology
|October 1, 1994
Summary
Ischemic preconditioning protects against heart damage. Evidence suggests this protective effect, observed in animals, also occurs in humans, offering potential for treating cardiovascular disorders.
Area of Science:
- Cardiology
- Physiology
Background:
- Ischemic preconditioning is a protective phenomenon against ischemic necrosis in animals.
- Its occurrence and mechanisms in humans remain under investigation.
Purpose of the Study:
- To evaluate the evidence for ischemic preconditioning in humans.
- To explore the potential clinical applications of preconditioning in cardiovascular medicine.
Main Methods:
- Review of studies on angioplasty, preinfarction angina, and exercise-induced ischemia.
- Analysis of cardiothoracic studies involving aortic cross-clamping.
- Examination of in vitro studies using human cardiac muscle and myocytes.
Main Results:
- Evidence supports preconditioning in humans through improved tolerance to ischemia during angioplasty and exercise.
- Some studies indicate a beneficial effect of preinfarction angina.
- In vitro studies confirm a biological basis for preconditioning in human cardiac tissues.
Conclusions:
- Ischemic preconditioning is likely a conserved protective mechanism in humans.
- Preconditioning or related agents hold promise for managing cardiovascular conditions like myocardial infarction and during cardiac procedures.