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Coronary angiographic findings do not predict clinical outcome in patients with unstable angina

F W Bär1, P Raynaud, J P Renkin

  • 1Center of the Unstable Angina Study Using Eminase (UNASEM) Group Academic Hospital Maastricht, University of Limburg, The Netherlands.

Journal of the American College of Cardiology
|November 15, 1994
PubMed

Insights

Thrombus formation and coronary artery lesion type did not predict clinical outcomes in unstable angina patients. This study found no correlation between these factors and changes in diameter stenosis or patient results.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Clinical Trials

Background:

  • Previous studies suggested thrombus formation and lesion type predict angiographic and clinical findings in unstable angina.
  • This retrospective analysis evaluated 159 patients from the Unstable Angina Study Using Eminase (UNASEM) trial.

Purpose of the Study:

  • To determine the presence and type of thrombus formation and coronary artery lesions in patients with unstable angina.
  • To correlate these findings with angiographic results and clinical outcomes.

Main Methods:

  • Included patients with unstable angina and ECG evidence of ischemia, excluding those with prior myocardial infarction.
  • Baseline and follow-up angiography were performed after administration of anistreplase or placebo.
  • 126 to 159 patients received study medication; 33 did not due to various reasons.

Main Results:

  • Anistreplase treatment significantly reduced diameter stenosis compared to placebo (11% vs. 3%, p=0.008).
  • No significant differences in clinical outcomes were observed between thrombolytic treatment and placebo (p=0.98).
  • Neither thrombus presence/absence nor lesion type correlated with diameter stenosis changes or clinical outcomes.

Conclusions:

  • In this cohort of unstable angina patients, coronary artery lesion type and thrombus formation do not predict clinical outcomes.
  • These findings suggest that focusing on lesion characteristics alone may not be sufficient for predicting patient prognosis in unstable angina.
Abstract

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