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Modification of the dissolution behaviour of a water-insoluble drug, naftazone, for zero-order release matrix
P Giunchedi1, L Maggi, A La Manna
1Department of Pharmaceutical Chemistry, University of Pavia, Italy.
The Journal of Pharmacy and Pharmacology
|June 1, 1994
Abstract:
The preparation of hydrophilic matrix tablets able to release naftazone, a water-insoluble drug, into an aqueous medium at a constant rate (zero-order dissolution) is described. Enhancement of dissolution rate of the drug was achieved using cross-linked carmellose sodium, beta-cyclodextrin or hydroxypropyl-beta-cyclodextrin. Hypromellose was used as a water-gelling polymer. Tablets could be prepared that released naftazone at a constant rate over 16 h.