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The effects of 4-aminopyridine on cognitive function in patients with multiple sclerosis: a pilot study
R C Smits1, H H Emmen, F W Bertelsmann
1Department of Neurology, Free University Hospital, Amsterdam, The Netherlands.
Neurology
|September 1, 1994
Abstract:
4-Aminopyridine (4-AP) has a favorable effect on the disability of certain patients with MS. We investigated the effect of 4-AP on neuropsychological performance in 20 MS patients using a randomized, double-blind, placebo-controlled, crossover design. Although there was a trend for improved performance with 4-AP for two of the tests, we could not demonstrate significant effects of 4-AP on cognitive function.