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Yale database for DNA sequence changes in mutagenesis
1Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06510.
Nucleic Acids Research
|September 1, 1994
Summary
The Yale database offers free access to over 17,000 genetic mutation sequences from bacteria, yeast, and mammals. This valuable resource is updated regularly and accessible online, aiding genetic research.
Area of Science:
- Genetics
- Molecular Biology
- Bioinformatics
Background:
- Genetic mutations are crucial for understanding gene function and disease.
- Comprehensive databases are essential for cataloging and analyzing mutation data.
- Existing resources may lack broad coverage across different species.
Purpose of the Study:
- To establish and maintain a comprehensive electronic database of genetic mutations.
- To provide researchers with free access to mutation sequence data.
- To facilitate the contribution of new mutation data by the scientific community.
Main Methods:
- Compilation of sequence changes from induced mutations in bacterial, mammalian, and yeast genes.
- Electronic data storage and management.
- Development of a data entry program (MUSTIN) for error minimization and data addition.
Main Results:
- The Yale database contains over 17,000 mutations as of July 1994.
- Data includes sequence changes in bacterial, mammalian, and yeast genes.
- The database is periodically updated and available electronically.
Conclusions:
- The Yale database serves as a significant, freely accessible resource for genetic mutation information.
- The database supports ongoing research by providing updated mutation data.
- The inclusion of a data entry program encourages community participation and data expansion.