Drug binding by reservoirs in elastomeric infusion devices

Area of Science:

• Pharmaceutical Science
• Drug Delivery Systems
• Materials Science

Background:

• Elastomeric infusion devices are widely used for continuous drug delivery.
• Potential drug-reservoir interactions can impact therapeutic efficacy.
• Quantifying drug binding is crucial for ensuring accurate dosing.

Purpose of the Study:

• To evaluate the drug binding capacity of elastomeric infusion device reservoirs.
• To determine if commonly infused drugs interact with reservoir materials.
• To establish a predictive model for drug-reservoir binding.

Main Methods:

• Assessed binding of 15 model solutes using equilibrium binding constants.
• Developed a binding model by regressing octanol/water and hexane/water partition coefficients.
• Determined partition coefficients for 17 common drugs in 0.9% Saline and 5% Dextrose formulations.

Main Results:

• The binding model successfully predicted solute binding.
• Most drugs exhibited very low octanol/formulation and hexane/formulation partition coefficients.
• Significant binding was not observed for the majority of tested drugs, with minimal loss (<2%) for fluconazole.

Conclusions:

• Elastomeric infusion device reservoirs are essentially inert regarding drug binding for the evaluated drugs.
• The study supports the use of these reservoirs without significant concern for drug adsorption.
• Accurate drug delivery is maintained as drug binding is negligible.