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[Resistance of pneumococcus]

F W Goldstein1

  • 1Hôpital Saint-Joseph, laboratoire de microbiologie médicale, Paris.

La Revue Du Praticien
|April 15, 1994
PubMed
Summary

Streptococcus pneumoniae resistance to penicillin G is rising due to altered penicillin-binding proteins. Testing minimal inhibitory concentrations for beta-lactams is crucial for serious infections.

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Area of Science:

  • Microbiology
  • Antibiotic Resistance
  • Pharmacology

Context:

  • Increasing resistance of Streptococcus pneumoniae to penicillin G and other antibiotics globally, particularly in France.
  • Penicillin G resistance mechanism involves modifications in penicillin-binding proteins (PBPs).
  • Cross-resistance to other beta-lactams varies based on drug affinity to modified PBPs.

Purpose:

  • To highlight the growing challenge of antibiotic resistance in S. pneumoniae.
  • To explain the molecular basis of penicillin G resistance in S. pneumoniae.
  • To emphasize the clinical necessity of determining antibiotic susceptibility.

Summary:

  • Penicillin G resistance in Streptococcus pneumoniae is escalating due to changes in penicillin-binding proteins.
  • This resistance affects all beta-lactams, with varying cross-resistance levels.
  • Minimal inhibitory concentration testing is vital for S. pneumoniae in severe infections.

Impact:

  • Informs clinical decisions for treating serious S. pneumoniae infections.
  • Guides antibiotic stewardship efforts to combat resistance.
  • Contributes to understanding beta-lactam antibiotic efficacy against resistant strains.

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