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[Resistance of pneumococcus]
1Hôpital Saint-Joseph, laboratoire de microbiologie médicale, Paris.
Abstract:
Resistance of S. pneumoniae to penicillin G and other useful antibiotics has sharply increase during the last years in many countries and especially in France. Resistance to penicillin G is due to an unpredictable qualitative and quantitative modification of several penicillin binding proteins. All the beta-lactams are affected but the level of cross-resistance depends upon the affinity of the beta-lactam for the modified penicillin binding proteins. As a consequence, the minimal inhibitory concentration of penicillin G and other useful beta-lactams have to be determined against S. pneumoniae isolated from serious infection, responsible for a clinical failure or resistant to penicillin G.
Insights
Streptococcus pneumoniae resistance to penicillin G is rising due to altered penicillin-binding proteins. Testing minimal inhibitory concentrations for beta-lactams is crucial for serious infections.
Area of Science:
- Microbiology
- Antibiotic Resistance
- Pharmacology
Context:
- Increasing resistance of Streptococcus pneumoniae to penicillin G and other antibiotics globally, particularly in France.
- Penicillin G resistance mechanism involves modifications in penicillin-binding proteins (PBPs).
- Cross-resistance to other beta-lactams varies based on drug affinity to modified PBPs.
Purpose:
- To highlight the growing challenge of antibiotic resistance in S. pneumoniae.
- To explain the molecular basis of penicillin G resistance in S. pneumoniae.
- To emphasize the clinical necessity of determining antibiotic susceptibility.
Summary:
- Penicillin G resistance in Streptococcus pneumoniae is escalating due to changes in penicillin-binding proteins.
- This resistance affects all beta-lactams, with varying cross-resistance levels.
- Minimal inhibitory concentration testing is vital for S. pneumoniae in severe infections.
Impact:
- Informs clinical decisions for treating serious S. pneumoniae infections.
- Guides antibiotic stewardship efforts to combat resistance.
- Contributes to understanding beta-lactam antibiotic efficacy against resistant strains.