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Effect of varicella zoster virus antigen-antibody complexes on hydrogen peroxide generation by human
T Fujiwara1, T Ihara, K Yamawaki
1Department of Pediatrics, Mie University, Japan.
Acta Paediatrica Japonica : Overseas Edition
|August 1, 1994
Abstract:
Hydrogen peroxide (H2O2) generation by human polymorphonuclear leukocytes (PMN) incubated with varicella zoster virus (VZV) antigen was studied by cytofluorography. Hydrogen peroxide generation was detected in the presence of VZV-seropositive sera. When seropositive sera were heat-inactivated, H2O2 generation was reduced. When PMN were pre-incubated with Leu-11b, a monoclonal antibody to the Fc receptor on PMN, H2O2 generation was also reduced. These results suggest that VZV antigen-antibody-complement complexes induce H2O2 generation by PMN after these complexes attach to Fc receptors on PMN.