Related Experiment Videos
Synthesis and biological activity of D-glucopyranosyl peptide T derivatives
M Marastoni1, S Spisani, R Tomatis
1Department of Pharmaceutical Science, University of Ferrara, Italy.
Arzneimittel-Forschung
|August 1, 1994
Abstract:
The solid phase procedure, based on the Fmoc (9-fluorenylmethyloxycarbonyl) chemistry, was used to prepare some peptide T analogues in which D-glucopyranosyl units are beta-O-glycosidically linked to Thr4 and/or Thr5 side chains. All glycopeptides showed significant human monocyte chemotaxis and high resistance to degradation by plasma or brain enzymes.