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Published on: October 17, 2009
Regulation of B-cell activation by CD45: a question of mechanism
L B Justement1, V K Brown, J Lin
1Dept of Microbiology and Immunology, University of Texas Medical Branch, Galveston 77555-1019.
Abstract:
Recent studies have demonstrated that the protein tyrosine phosphatase CD45 plays an integral role in regulation of B-cell function. Most notably, expression of this phosphatase is required for activation of B lymphocytes and entry into the cell cycle. Here, Louis Justement and colleagues review current information concerning the function of CD45 in the B cell. The discussion focuses on two questions that are of central importance: what are the physiological substrates for CD45 and how does reversible tyrosine phosphorylation affect their function?
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