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Related Experiment Videos

Immunity to a parasite that transforms T lymphocytes

D J McKeever1, W I Morrison

  • 1International Laboratory for Research in Animal Diseases, Nairobi, Kenya.

Current Opinion in Immunology
|August 1, 1994
PubMed
Summary

Cattle can be protected from Theileria parva infection by parasite-specific CD8+ T cells. Ongoing immunization trials with a neutralizing vaccine candidate show promise for improved cattle parasite control.

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Genotypic diversity, a survival strategy for the apicomplexan parasite Theileria parva.

Veterinary parasitology·2009

Area of Science:

  • Veterinary immunology
  • Parasitology
  • Vaccine development

Background:

  • Theileria parva causes significant cattle disease.
  • Effective vaccines against Theileria parva are needed.

Purpose of the Study:

  • To present evidence for CD8+ T cell-mediated protection against Theileria parva.
  • To update on progress in developing a neutralizing vaccine for Theileria parva.

Main Methods:

  • Adoptive transfer of parasite-specific lymphocytes between monozygous twin cattle.
  • Immunization trials using a vaccine targeting the T. parva sporozoite surface antigen.

Main Results:

  • Demonstrated direct evidence of CD8+ T cell-mediated protection against patent infection.
  • Immunization trials with a candidate vaccine are ongoing and progressing.

Conclusions:

  • Parasite-specific CD8+ T cells are crucial for cattle immunity against Theileria parva.
  • Advancements in vaccine development offer improved prospects for controlling Theileria parva infections.

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