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Related Experiment Videos

Abnormal subendocardial function in restrictive left ventricular disease

M Y Henein1, D G Gibson

  • 1Cardiac Department, Royal Brompton National Heart and Lung Hospital, London.

British Heart Journal
|September 1, 1994
PubMed
Summary
This summary is machine-generated.

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Left ventricular long axis function is impaired in patients with restrictive filling patterns, affecting both systolic shortening and diastolic lengthening. These abnormalities in motion impact overall heart function and may be treatable.

Area of Science:

  • Cardiology
  • Cardiac Physiology
  • Echocardiography

Background:

  • Restrictive filling patterns indicate impaired diastolic function.
  • Left ventricular long axis function is crucial for overall cardiac performance.

Purpose of the Study:

  • To investigate disturbances in left ventricular long axis function in patients with restrictive filling patterns.
  • To assess if these abnormalities differ based on left ventricular cavity size.

Main Methods:

  • Prospective study involving echocardiography to assess left ventricular transverse and longitudinal axes, transmitral flow, and apexcardiogram.
  • Compared 30 patients with restrictive filling patterns to 21 normal subjects.

Main Results:

  • Patients with restrictive filling patterns showed reduced left ventricular long axis motion amplitude and peak shortening/lengthening velocities.

Related Experiment Videos

  • Diastolic long axis function, including early diastolic lengthening rate and atrial systole amplitude, was impaired.
  • These abnormalities were present regardless of left ventricular cavity size (normal or dilated).

    • Conclusions:

    • Left ventricular long axis dysfunction is a consistent finding in restrictive heart disease.
    • Impaired long axis motion affects both systolic and diastolic function, independent of passive cavity compliance.
    • These long axis abnormalities are potentially treatable, unlike myocardial fibrosis.