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Cloning and characterization of a cDNA encoding rat PKR, the double-stranded RNA-dependent eukaryotic initiation
H Mellor1, K M Flowers, S R Kimball
1Department of Cellular and Molecular Physiology, College of Medicine, Pennsylvania State University, Hershey 17033.
Biochimica Et Biophysica Acta
|November 22, 1994
Abstract:
We have isolated and sequenced a full-length cDNA encoding the double-stranded RNA-dependent protein kinase PKR from rat. The derived amino acid sequences of the protein kinase and RNA-binding domains are highly conserved between the rat, human and mouse enzymes. In addition, sequence elements in the 5'- and 3'-untranslated regions are also conserved between species.