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HLA phenotypes and multiple basal cell carcinomas

R Rompel1, J Petres, K Kaupert

  • 1Department of Dermatology, Municipal Classics of Kassel, Germany.

Dermatology (Basel, Switzerland)
|January 1, 1994
PubMed
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This study investigated the link between human leukocyte antigen (HLA) types and multiple basal cell carcinomas (BCCs). Findings suggest the HLA system plays a minimal role in the development of multiple BCCs.

Area of Science:

  • Immunogenetics
  • Dermatology
  • Cancer Research

Background:

  • Previous research suggested a link between human leukocyte antigen (HLA) and multiple basal cell carcinomas (BCCs), but findings were inconsistent.
  • The association between specific HLA antigens and BCC development requires further clarification.

Purpose of the Study:

  • To objectively investigate and confirm previously reported associations between HLA antigens and multiple BCCs.
  • To determine the significance of HLA antigen frequencies in patients with multiple BCCs.

Main Methods:

  • Serologic HLA typing was performed on 49 unrelated patients diagnosed with five or more BCCs.
  • Class I and class II HLA antigens were analyzed in patients and compared to healthy controls (n=716).

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Main Results:

  • A decreased frequency of HLA-DR4 was observed in patients with multiple BCCs compared to controls.
  • Increased frequencies of Cw7 were noted in the overall patient group and a subgroup with facial BCCs.
  • Subgroups with BCCs predominantly on the trunk showed increased frequencies of HLA-A11, -B17, -B22, and -Cw3, though these were not statistically significant after correction.

Conclusions:

  • The human leukocyte antigen (HLA) system appears to play a minor role, if any, in the pathogenesis of multiple basal cell carcinomas.
  • The observed antigen frequency deviations did not reach statistical significance, indicating a weak or negligible association.