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[Sinushistiocytosis with massive lymphadenopathy (Rosai-Dorfman disease)]
M R Becker1, T Gaiser, R Rompel
1Hautklinik, Klinikum Kassel. maria.becker@web.de
Abstract:
Sinus histiocytosis with massive lymphadenopathy (SHML) is a rare, painless lymphoproliferative disorder of unknown origin with a usually benign course. About 40% of the patients show an extranodal involvement with skin being the most common site in 27% of these patients. We describe a patient with widespread disease involving the respiratory tract, kidneys and skin. Histopathology revealed the characteristic features of SHML with emperipolesis and immunohistochemical positivity of histiocytes for S100 and macrophage-associated antigens.
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