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Thyroid function screening in newly admitted psychiatric inpatients

W G Ryan1, R F Roddam, W E Grizzle

  • 1Department of Psychiatry, University of Alabama School of Medicine, Birmingham.

Annals of Clinical Psychiatry : Official Journal of the American Academy of Clinical Psychiatrists
|March 1, 1994
PubMed
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Thyroid function tests revealed abnormalities in 12.3% of psychiatric patients. Depressed patients showed lower T4 and free thyroxine index levels compared to those with mania or schizophrenia, suggesting a link between thyroid function and psychiatric diagnosis.

Area of Science:

  • Neuropsychiatry
  • Endocrinology
  • Clinical Diagnostics

Background:

  • Thyroid dysfunction is frequently observed in psychiatric populations.
  • Previous studies have indicated a higher prevalence of thyroid abnormalities in individuals with mental health disorders.

Purpose of the Study:

  • To investigate the prevalence of thyroid dysfunction in acute psychiatric admissions.
  • To explore potential differences in thyroid function test results among various psychiatric diagnoses.

Main Methods:

  • Thyroid function tests, including T4, T3RU, and free thyroxine index, were conducted on 269 acute psychiatric patients upon admission.
  • Data were collected over a 2-year period.

Main Results:

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  • Thyroid disease was detected in 3% of patients, and euthyroid abnormalities were found in 9.3%.
  • Significantly lower T4 and free thyroxine index levels were observed in patients diagnosed with depression compared to those with mania or schizophrenia.
  • The overall rate of abnormal thyroid tests was lower than reported in previous surveys.
  • Conclusions:

    • Thyroid function test abnormalities are present in a notable percentage of acute psychiatric admissions.
    • Distinct patterns of thyroid function test results may correlate with specific psychiatric diagnoses, particularly depression.
    • Further research is warranted to elucidate the relationship between thyroid function and psychiatric conditions, considering potential influences of laboratory techniques and population demographics.