[Intracellular interactions in the hematopoietic system after massive radiation exposure]

The review article deals with acute radiation damage to the bone marrow spatial structure, disturbances of cell-cell interactions, and stromal cytokine(s) production, hence representing limiting factors for effective postradiation recovery of blood system. The evidence for radiation-induced stromal functional activation is discussed, along with opportunity of local growth factors deficiency, thus requiring a replacement therapy with exogenous cytokines.