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Related Experiment Videos

Voluntary saccadic oscillations, resembling ocular flutter and opsoclonus

R D Yee1, P H Spiegel, T Yamada

  • 1Department of Ophthalmology, Indiana University School of Medicine, Indianapolis 46202.

Journal of Neuro-Ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society
|June 1, 1994
PubMed
Summary

Healthy individuals can intentionally create large, rapid eye movements similar to neurological disorders. These voluntary saccadic oscillations mimic ocular flutter and opsoclonus, demonstrating a novel form of fixation instability.

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Area of Science:

  • Neuroscience
  • Ophthalmology
  • Human Physiology

Background:

  • Ocular flutter and opsoclonus are involuntary saccadic oscillations often associated with neurological disorders.
  • These conditions typically involve the brainstem and cerebellum.
  • Previous research has focused on pathological causes of these eye movements.

Purpose of the Study:

  • To investigate the possibility of voluntarily producing saccadic oscillations.
  • To characterize the features of intentionally generated eye movements resembling ocular flutter and opsoclonus.
  • To differentiate voluntary fixation instabilities from pathological conditions.

Main Methods:

  • Recruitment of two healthy human subjects with no prior neurological conditions.
  • Recording of eye movements using DC electro-oculography and/or magnetic scleral search coil.

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  • Analysis of saccade characteristics, including direction, amplitude, trajectory, and intervals.

    • Main Results:

    • Subjects produced large-amplitude, to-and-fro saccadic oscillations, with one subject doing so intentionally.
    • The movements were conjugate saccades in opposing directions without intersaccadic intervals.
    • These voluntary oscillations were multidirectional, with amplitudes up to 40 degrees and linear or curvilinear trajectories, closely resembling pathological ocular flutter and opsoclonus.

    Conclusions:

    • Fixation instabilities similar to ocular flutter and opsoclonus can be intentionally produced by healthy individuals.
    • These findings highlight the brain's capacity for complex voluntary motor control, even in mimicking pathological movements.
    • The study expands our understanding of saccadic control and voluntary eye movement generation.