[The effect of shigellae on delayed hypersensitivity in mice infected by different routes]

The influence of virulent and avirulent shigellae on delayed hypersensitivity in the case of infection by different methods has been examined. It was found that the stimulating effect of avirulent shigellae and suppressive effect of virulent shigellae were displayed after intranasal infection. Intraperitoneal and intravenous infection was accompanied by only immunosuppressive influence, which was displayed by the virulent bacteria. The discrimination of T-suppressors by low doses of cyclophosphamide did not abolish the suppressive effect of shigellae. At the same time immunosuppressive factor of spleen was produced equally after infection by different-virulence shigellae. A conclusion was drawn that T-suppressors and immunosuppressive spleen factor did not take part in the mechanism of shigellae immunosuppression.