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Allergic models and cytokines
1Department of Internal Medicine, University of Iowa College of Medicine, Iowa City.
American Journal of Respiratory and Critical Care Medicine
|November 1, 1994
Summary
Cytokines are key inflammatory proteins released during allergic reactions. Blocking these cytokine effects may reduce allergic inflammation and asthma symptoms.
Area of Science:
- Immunology
- Allergy Research
- Cell Biology
Background:
- Cytokines are proinflammatory mediators produced by various immune and non-immune cells.
- Cytokine release is a known consequence of allergic reactions.
- These proteins play a central role in mediating allergic inflammation.
Purpose of the Study:
- To review in vitro and in vivo studies on cytokine production and regulation in allergic models.
- To discuss the specific roles of cytokines in allergic inflammation and asthma.
- To explore the potential of cytokine antagonists in blocking pro-inflammatory effects.
Main Methods:
- Review of in vitro studies.
- Review of in vivo animal studies.
- Review of human studies in allergic models.
Main Results:
- Cytokines activate eosinophils, promote mast cell development, and regulate IgE.
- Cytokines modulate adhesion molecules and guide neutrophil and eosinophil chemotaxis.
- Evidence suggests cytokine antagonists can block pro-inflammatory effects.
Conclusions:
- Cytokines are critical mediators of allergic inflammation and asthma.
- Targeting cytokines offers a potential therapeutic strategy for allergic diseases.