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Prolonged effect of inhaled salmeterol against exercise-induced bronchospasm
J P Kemp1, R J Dockhorn, W W Busse
1Allergy and Asthma Medical Group and Research Center, San Diego, California 92123.
American Journal of Respiratory and Critical Care Medicine
|December 1, 1994
Summary
Salmeterol effectively prevents exercise-induced bronchospasm (EIB) for up to 12 hours. A single dose provided sustained protection in most subjects, unlike albuterol, showing salmeterol
Area of Science:
- Pulmonology
- Pharmacology
- Exercise Physiology
Background:
- Physical exercise commonly triggers bronchial asthma.
- Exercise-induced bronchospasm (EIB) significantly impacts asthma patients' quality of life.
- Long-acting bronchodilators are explored for EIB prevention.
Purpose of the Study:
- To evaluate the preventive effect of a single 42 mcg dose of salmeterol on EIB.
- To compare the efficacy of salmeterol with albuterol in preventing EIB.
- To assess the duration of protection offered by salmeterol against EIB.
Main Methods:
- Two independent, randomized, double-blind, placebo-controlled studies.
- 161 subjects with asthma underwent three exercise challenges over 12 hours.
- Bronchoconstriction was assessed by measuring changes in FEV1 post-exercise compared to pre-dose values.
Main Results:
- Salmeterol showed a significantly lower mean maximal percentage decrease in FEV1 compared to albuterol and placebo across all challenges (p < 0.001).
- Salmeterol provided complete protection against EIB in 55-80% of subjects for up to 11.5 hours post-dose.
- Albuterol offered complete protection only after the first exercise challenge.
Conclusions:
- A single 42 mcg dose of salmeterol effectively prevents EIB for up to 12 hours.
- Salmeterol demonstrates superior and more sustained protection against EIB compared to albuterol.
- Salmeterol is a viable therapeutic option for managing exercise-induced bronchospasm.