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A molecular evolutionary framework for eukaryotic model organisms

A Sidow1, W K Thomas

  • 1Department of Molecular and Cell Biology, University of California, Berkeley 94720-3202.

Current Biology : CB
|July 1, 1994
PubMed
Summary
This summary is machine-generated.

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RNA polymerase II aids in understanding eukaryotic evolution. This study reveals evolutionary relationships, showing plants and animals share an ancestor excluding fungi, and places Caenorhabditis elegans early in metazoan divergence.

Area of Science:

  • Molecular Evolution
  • Developmental Biology
  • Cell Biology

Background:

  • Understanding model organism biology requires knowing their phylogenetic position.
  • Major model organisms in developmental and cell biology are examined.
  • Evolutionary relationships of fungi, plants, and animals are considered.

Purpose of the Study:

  • To determine the phylogenetic positions of key model organisms.
  • To establish evolutionary relationships among major eukaryotic groups.
  • To assess RNA polymerase II as a tool for phylogenetic analysis.

Main Methods:

  • Comparative analysis of small subunit ribosomal RNA (18S rRNA).
  • Phylogenetic analysis using sequences of the two largest subunits of RNA polymerase II.

Related Experiment Videos

  • Integration of newly determined and published sequence data.

    • Main Results:

    • RNA polymerase II is effective for resolving early eukaryotic phylogenetic branchings.
    • Plants and animals share a common ancestor, excluding fungi.
    • The lineage of Caenorhabditis elegans diverged earlier from Metazoa than other major animal groups.
    • Deuterostomes are shown to have arisen from within protostomes.

    Conclusions:

    • RNA polymerase II is a suitable molecule for elucidating eukaryotic evolutionary relationships.
    • A robust phylogenetic framework enables predictions about conserved biological mechanisms across species.
    • Insights from model organisms can be extended to other biological disciplines.