Related Experiment Video
Updated: Aug 19, 2026

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
Published on: March 26, 2018
Chronic leukemias
1Section of Hematology/Oncology, VA Medical Center, Minneapolis, Minnesota.
Abstract:
Chronic leukemias include a broad spectrum of disorders generally characterized by uncontrolled proliferation of mature, differentiated cells of the hematopoietic system. Clinical manifestations and treatment strategies vary widely among the disorders. In some cases, immediate aggressive treatment is required; while in others, it is more appropriate to withhold immediate treatment and perhaps not treat at all. This article reviews the pathologic features, clinical characteristics, and treatment of chronic leukemias.
Related Concept Videos
Multipotency of Hematopoietic Stem Cells
Lineage Commitment
Differentiation of Common Myeloid Progenitor Cells
Structure and Function of Leukocytes
White blood cells protect the body...
Disorders of Leukocytes
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...
Bone Marrow Sampling and Transplants
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...

