[Amniotic fluid C-peptide in pregnancy with diabetes]

A prospective study on amniotic fluid C-peptide (AFCP) was made in 29 women with diabetic pregnancy and 23 non-diabetic control subjects. The mean concentrations of AFCP were found to be significantly higher in diabetic pregnancy than in non-diabetic pregnancy (P < 0.01) (diabetic group AFCP 1.89 +/- 1.53ng/ml; control group 0.88 +/- 0.51ng/ml). AFCP levels were related to the degree of blood glucose control during pregnancy and not to diabetic classification. The results show that fetal hyperinsulinemia reduced in these women that the achieved metabolic control of maternal blood glucose levels approached normal values. A higher neonatal complications occurred while AFCP was over 1.68ng/ml.