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Related Experiment Videos

The pattern visual evoked potential. A multicenter study using standardized techniques

M Brigell1, D I Kaufman, P Bobak

  • 1Department of Neurology, Loyola University Chicago, Maywood, IL.

Documenta Ophthalmologica. Advances in Ophthalmology
|January 1, 1994
PubMed
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Standardizing pattern-reversal visual evoked potential (PVEP) testing across multiple centers is feasible. This allows PVEP to be used in clinical trials for optic nerve conditions like multiple sclerosis.

Area of Science:

  • Neuroscience
  • Ophthalmology
  • Clinical Neurology

Background:

  • Pattern-reversal visual evoked potential (PVEP) measures optic nerve conduction delay.
  • Demyelination, as seen in optic neuropathy and multiple sclerosis, affects PVEP.
  • Previous multicenter trials were limited by standardization challenges.

Purpose of the Study:

  • To determine if PVEP can be standardized for multicenter therapeutic trials.
  • To assess PVEP's utility in optic neuropathy and multiple sclerosis trials.

Main Methods:

  • Equated stimulus and recording variables across four research centers.
  • Recorded PVEP in 64 healthy individuals and 15 patients with resolved optic neuritis.

Main Results:

Related Experiment Videos

  • Latency and amplitude data were consistent across all participating centers.
  • N70 and P100 peak latencies and N70-P100 interocular amplitude difference effectively identified resolved optic neuritis.

Conclusions:

  • PVEP testing can be satisfactorily standardized for multicenter clinical trials.
  • PVEP is a sensitive measure for evaluating optic nerve conduction in demyelinating diseases.