Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Posttraumatic seizures

E M Dugan1, J M Howell

  • 1Department of Emergency Medicine, Georgetown University Hospital, Washington, DC.

Emergency Medicine Clinics of North America
|November 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Cutaneous Assessment Tool: development and reliability in juvenile idiopathic inflammatory myopathy.

Rheumatology (Oxford, England)·2007
Same author

Injection of a recombinant AAV serotype 2 into canine skeletal muscles evokes strong immune responses against transgene products.

Gene therapy·2007
Same author

Lack of toxicity from pediatric beta-blocker exposures.

Human & experimental toxicology·2006
Same author

Evaluation of a short interspersed nucleotide element in the 3' untranslated region of the defective dystrophin gene of dogs with muscular dystrophy.

American journal of veterinary research·2002
Same author

Characterization of the 5'-sequence of the mouse fatty acid amide hydrolase.

Neuroscience letters·2001
Same author

Dystrophin expression in muscle following gene transfer with a fully deleted ("gutted") adenovirus is markedly improved by trans-acting adenoviral gene products.

Human gene therapy·2001
Same journal

Why Dispelling Myths and Misconceptions in Emergency Medicine Matters.

Emergency medicine clinics of North America·2026
Same journal

Myths and Misconceptions in Emergency Medicine.

Emergency medicine clinics of North America·2026
Same journal

Acute Otitis Media-Watch and Wait Is Not a Myth.

Emergency medicine clinics of North America·2026
Same journal

Hot or Not? Myths and Misconceptions About Antipyretics for Pediatric Fever.

Emergency medicine clinics of North America·2026
Same journal

Epinephrine Improves Outcomes in Out-Of-Hospital Cardiac Arrests.

Emergency medicine clinics of North America·2026
Same journal

Myth: Pretreatment Prevents Intravenous Contrast Reactions in the Emergency Department.

Emergency medicine clinics of North America·2026
See all related articles

Posttraumatic epilepsy after head trauma is difficult to predict. This review covers brain injury mechanisms, biochemical effects, and therapies like antiepileptic prophylaxis and neuroprotection.

Area of Science:

  • Neuroscience
  • Neurology
  • Traumatology

Background:

  • Posttraumatic epilepsy (PTE) is a significant challenge following head trauma.
  • Predicting PTE development remains difficult, impacting patient outcomes.
  • Understanding the underlying mechanisms is crucial for effective management.

Purpose of the Study:

  • To explore the mechanisms and biochemical effects of brain injury.
  • To examine the relationship between brain injury and seizure development.
  • To review antiepileptic prophylaxis and neuroprotective pharmacologic therapies for PTE.

Main Methods:

  • Literature review of studies on head trauma and epilepsy.
  • Analysis of biochemical effects and molecular pathways in brain injury.

Related Experiment Videos

  • Synthesis of current knowledge on PTE prevention and treatment.

    • Main Results:

    • Head trauma triggers complex biochemical cascades leading to neuronal hyperexcitability.
    • Specific injury mechanisms correlate with increased seizure risk.
    • Pharmacologic interventions show potential in mitigating PTE.

    Conclusions:

    • Effective prediction and prevention of PTE require a comprehensive understanding of injury mechanisms.
    • Antiepileptic prophylaxis and neuroprotection are promising therapeutic strategies.
    • Further research is needed to optimize neuroprotective and antiepileptic treatments for head trauma survivors.