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Does topical flurbiprofen affect the pupillary response to acetylcholine?
H Jackson1, C K Patel, M Westcott
1Department of Ophthalmology, St George's Hospital, London, UK.
Eye (London, England)
|January 1, 1994
Summary
Pre-operative topical non-steroidal anti-inflammatory drugs (NSAIDs) maintain pupil dilation during cataract surgery. This study found that flurbiprofen does not interfere with the pupil-constricting effect of acetylcholine.
Area of Science:
- Ophthalmology
- Pharmacology
Background:
- Topical non-steroidal anti-inflammatory drugs (NSAIDs) are used to maintain pupillary dilation during cataract surgery.
- Concerns exist that NSAID pre-treatment may blunt the miosis response to intraoperative acetylcholine.
Purpose of the Study:
- To investigate if pre-operative topical flurbiprofen 0.03% reduces the pupillary response to intraoperative acetylcholine injection.
- To evaluate the effect of flurbiprofen on maintaining pupillary dilation during cataract surgery.
Main Methods:
- Pupil diameters were measured using a millimetre rule and verified with computerized image analysis.
- A comparison was made between eyes treated with topical flurbiprofen and control eyes.
Main Results:
- No significant difference in pupillary diameter was observed before corneal incision between groups.
- The flurbiprofen group maintained a significantly larger pupil after lens aspiration and intraocular lens insertion (p = 0.002).
- No significant difference in the degree of miosis was detected at 1.0, 2.5, and 5.0 minutes post-acetylcholine injection.
Conclusions:
- Topical flurbiprofen effectively maintains pupillary dilation throughout cataract surgery.
- Pre-operative topical flurbiprofen does not impair the intraoperative pupillary response to acetylcholine injection.