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Disseminated intra-cerebral microabscesses: a clinico-pathologic study

V V Radhakrishnan1, A Saraswathy, D Rout

  • 1Department of Pathology, Sree Chitra Tirunal Institute for Medical Science and Technology, Trivandrum.

Indian Journal of Pathology & Microbiology
|April 1, 1994
PubMed
Summary

Disseminated intracerebral microabscesses, often undetected during life, are a significant finding in unexplained encephalopathy. Autopsies revealed these microabscesses as the primary cause of death in eight patients.

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Area of Science:

  • Neuropathology
  • Infectious Diseases
  • Neuroscience

Background:

  • Disseminated intracerebral microabscesses are a rare but serious condition.
  • Diagnosis is often challenging due to non-specific clinical presentations.
  • Encephalopathy of unknown etiology requires thorough investigation.

Purpose of the Study:

  • To analyze the clinical and neuropathological features of disseminated intracerebral microabscesses.
  • To highlight the diagnostic challenges and autopsy findings in such cases.
  • To emphasize the importance of considering microabscesses in the differential diagnosis of encephalopathy.

Main Methods:

  • Retrospective analysis of clinical and neuropathological data.
  • Review of eight patient cases with disseminated intracerebral microabscesses.

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  • Autopsy examination to identify causative agents.

    • Main Results:

    • All eight patients presented with acute encephalopathy.
    • Neuroradiological and laboratory tests were inconclusive for diagnosis.
    • Autopsy revealed disseminated microabscesses as the main pathological finding.
    • Microbial agents identified included Candida albicans, Gram-negative bacilli, and Gram-positive cocci.

    Conclusions:

    • Disseminated intracerebral microabscesses are frequently unrecognized during life.
    • These microabscesses are a critical consideration in the differential diagnosis of acute encephalopathy.
    • Prompt identification and treatment of CNS infections are crucial.