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Laryngectomy alone for T3 glottic cancer
R L Foote1, K D Olsen, S J Buskirk
1Division of Radiation Oncology, Mayo Clinic, Rochester, Minnesota 55905.
Head & Neck
|September 1, 1994
Summary
For T3 glottic cancer patients treated with laryngectomy alone, subglottic extension and nodal metastasis predict recurrence above the clavicles, especially in undissected necks. Long-term survival rates are presented.
Area of Science:
- Otolaryngology
- Head and Neck Surgery
- Oncology
Background:
- Study focuses on 81 patients with T3 squamous cell carcinoma of the glottic larynx.
- Treatment involved laryngectomy alone.
- Identifies pathologic predictors for cancer recurrence and death.
Purpose of the Study:
- To present long-term survival data for T3 glottic laryngeal cancer patients treated with laryngectomy.
- To identify pathologic predictors of cancer recurrence above the clavicles.
- To identify pathologic predictors of cancer death.
Main Methods:
- Retrospective review of clinical records, operative notes, and pathology slides.
- Follow-up until death or a minimum of 10.8 years.
- Endpoints included failure above clavicles, cause-specific survival, and overall survival.
Main Results:
- The primary failure pattern was neck metastasis (ipsilateral or contralateral).
- Subglottic extension and nodal metastases predicted failure above the clavicles.
- Five-year rates: disease control 74.1%, cause-specific survival 73.7%, overall survival 54.3%.
Conclusions:
- Laryngectomy for T3 glottic cancer with subglottic extension or nodal metastasis indicates higher risk of recurrence.
- Recurrence risk is elevated, particularly in undissected necks.
- Pathologic findings are crucial for predicting outcomes in these patients.