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Novel antibiotics, amythiamicins. II. Structure elucidation of amythiamicin D
K Shimanaka1, Y Takahashi, H Iinuma
1Institute of Microbial Chemistry, Microbial Chemistry Research Foundation, Tokyo, Japan.
The Journal of Antibiotics
|October 1, 1994
Abstract:
The structure of a unique polythiazole-containing cyclic peptide antibiotic, amythiamicin D, was elucidated by chemical degradations and NMR spectral analyses. Acid hydrolysis of amythiamicin D gave one mole of glycine and three new amino acids. Structures of N-acetyl-O-methyl derivatives of these new amino acids were determined by NMR and UV spectral analyses. Connectivities of these amino acids were determined by HMBC experiments.