Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Clozapine, negative symptoms, and extrapyramidal side effects

J M Kane1, A Z Safferman, S Pollack

  • 1Hillside Hospital, Division of Long Island Jewish Medical Center, Glen Oaks, N.Y. 11004.

The Journal of Clinical Psychiatry
|September 1, 1994
PubMed
Summary

Persistent negative symptoms in schizophrenia hinder rehabilitation. Clozapine treatment showed correlations between akinesia and anergia, suggesting drug-induced parkinsonism may complicate negative symptom assessment.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The treatment effect of rivaroxaban on clot characteristics in patients who present acutely with first time deep vein thrombosis.

Clinical hemorheology and microcirculation·2021
Same author

Hippocampal dysfunction in the pathophysiology of schizophrenia: a selective review and hypothesis for early detection and intervention.

Molecular psychiatry·2018
Same author

Baseline demographics, clinical features and predictors of conversion among 200 individuals in a longitudinal prospective psychosis-risk cohort.

Psychological medicine·2017
Same author

Probable metronidazole induced serum sickness-like reaction in a paediatric patient.

Journal of clinical pharmacy and therapeutics·2016
Same author

The role of the ITIH3 rs2535629 variant in antipsychotic response.

Schizophrenia research·2016
Same author

Genome-wide association study on antipsychotic-induced weight gain in the CATIE sample.

The pharmacogenomics journal·2015

Area of Science:

  • Psychiatry
  • Neuroscience
  • Pharmacology

Background:

  • Persistent negative symptoms significantly impede psychosocial and vocational rehabilitation in schizophrenia patients.
  • Current treatment trials and drug development increasingly target negative symptoms.
  • Neuroleptic-induced parkinsonism shares phenomenological overlap with negative symptoms, complicating assessment.

Purpose of the Study:

  • To investigate the relationship between negative symptoms and neuroleptic-induced parkinsonism in clozapine-treated schizophrenia patients.
  • To assess the impact of drug-induced parkinsonism on the evaluation of negative symptoms.

Main Methods:

  • Analysis of data from a cohort of 56 patients treated with clozapine.
  • Assessment of negative symptoms and parkinsonian side effects, including measures of akinesia and anergia.

Related Experiment Videos

  • Inclusion of patients with an average drug washout period exceeding two weeks.

    • Main Results:

    • Significant correlations were observed between measures of akinesia and anergia in clozapine-treated patients.
    • The persistence of drug-induced parkinsonism was noted even after a substantial drug washout period.

    Conclusions:

    • Drug-induced parkinsonism, specifically akinesia, is significantly correlated with negative symptoms like anergia in schizophrenia.
    • The persistent nature of drug-induced parkinsonism can confound the accurate assessment of therapeutic effects on negative symptoms in clinical trials and treatment monitoring.