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Microflora in postirradiated cancer cervix

B D Chatterjee¹, C K Chakraborti

¹Department of Bacteriology and Serology, School of Tropical Medicine, Calcutta.

Journal of the Indian Medical Association

|July 1, 1994

Summary

Cancer cervix patients undergoing radiation therapy show increased anaerobic bacteria and decreased aerobic bacteria compared to healthy individuals. Specific bacteria like Peptococcus prevotii and Staph aureus were more prevalent in these patients.

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Area of Science:

Microbiology
Oncology

Background:

The vaginal microbiome plays a role in women's health.
Alterations in the vaginal microbiome are associated with various conditions, including cervical cancer.

Purpose of the Study:

To investigate the differences in aerobic and anaerobic bacterial flora in patients with cancer cervix compared to normal controls.
To identify specific bacterial species prevalent in cancer cervix cases, particularly in stage III elderly patients.

Main Methods:

Comparative analysis of bacterial flora (aerobic and anaerobic) in cancer cervix patients and normal controls.
Identification and quantification of specific bacterial genera and species using microbiological techniques.

Main Results:

Cancer cervix patients exhibited a higher prevalence of anaerobes (50%) compared to normal controls (44.6%).
Aerobic organisms were suppressed in cancer cervix cases (63.6%) versus normal controls (90.7%).
Gram-negative bacilli, Peptococcus prevotii, Bacteroides oralis, Staph aureus, and Klebsiella were significantly more prevalent in cancer cervix patients.

Conclusions:

The altered bacterial flora in cancer cervix patients, especially in stage III elderly individuals, suggests a potential role for these microorganisms in the disease.
The findings may support the consideration of antibacterial therapy in managing cancer cervix, particularly in specific patient groups.

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