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Related Experiment Videos

A fatal ketamine poisoning

M Licata1, G Pierini, G Popoli

  • 1Institute of Legal Medicine, University of Modena, Italy.

Journal of Forensic Sciences
|September 1, 1994
PubMed
Summary
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This case report details a fatal ketamine overdose, highlighting a homicide motivated by sexual orientation. A new extraction method efficiently detects ketamine in biological samples for forensic analysis.

Area of Science:

  • Forensic Toxicology
  • Analytical Chemistry
  • Pharmacology

Background:

  • Ketamine is an anesthetic with potential for abuse and forensic implications.
  • Accurate detection of ketamine and its metabolites in biological samples is crucial for forensic investigations.
  • Novel analytical methods are needed to improve efficiency and recovery rates in toxicological analyses.

Observation:

  • An unusual case of death attributed to ketamine overdose, involving homicide, is presented.
  • The victim's death was linked to a crime motivated by homosexual intent.
  • Ketamine and its metabolite, Nor-Ketamine, were detected in various biological fluids and tissues.

Findings:

  • A rapid and effective solid-phase extraction (SPE) procedure using Bond-Elute C18 was developed for ketamine and Nor-Ketamine.

Related Experiment Videos

  • The SPE method demonstrated a 75% recovery rate for ketamine.
  • Gas-chromatography (GLC) and gas-chromatography/mass spectrometry (GC-MS) were employed for drug analysis.
  • Quantification of ketamine in blood, urine, bile, brain, liver, and kidney tissues was achieved, with Nor-Ketamine detected but not quantified.

    • Implications:

    • The developed SPE method offers a reliable approach for detecting ketamine in forensic toxicology.
    • This study contributes to the understanding of ketamine's role in forensic cases, including homicides.
    • Improved analytical techniques enhance the ability to identify and quantify drugs in post-mortem investigations.