Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Cortical tangles in progressive supranuclear palsy

M Verny¹, C Duyckaerts, P Delaère

¹Laboratoire de Neuropathologie R. Escourolle, Hôpital de La Salpêtrière, Paris, France.

Journal of Neural Transmission. Supplementum

|January 1, 1994

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

STochastic Optical Reconstruction Microscopy (STORM) reveals the nanoscale organization of pathological aggregates in human brain.

Neuropathology and applied neurobiology·2020

Same author

Cognitive deficit, and neuropathological correlates, in the oldest-old.

Revue neurologique·2020

Same author

[Spreading of protein misfolding: A new paradigm in neurology].

Revue neurologique·2015

Same author

Modifications of the endosomal compartment in peripheral blood mononuclear cells and fibroblasts from Alzheimer's disease patients.

Translational psychiatry·2015

Same author

Sicca syndrome and dementia in a patient with hepatitis C infection: a case report with unusual bifocal extrahepatic manifestations.

Journal of maxillofacial and oral surgery·2015

Same author

Frontotemporal lobar degeneration: diversity of FTLD lesions.

Revue neurologique·2013

Same journal

Intake of tomato-enriched diet protects from 6-hydroxydopamine-induced degeneration of rat nigral dopaminergic neurons.

Journal of neural transmission. Supplementum·2010

Same journal

A diet for dopaminergic neurons?

Journal of neural transmission. Supplementum·2010

Same journal

Immunization as treatment for Parkinson's disease.

Journal of neural transmission. Supplementum·2010

Same journal

Gene therapy for Parkinson's disease.

Journal of neural transmission. Supplementum·2010

Same journal

Stem cells and cell replacement therapy for Parkinson's disease.

Journal of neural transmission. Supplementum·2010

Same journal

Neurogenesis in substantia nigra of parkinsonian brains?

Journal of neural transmission. Supplementum·2010

See all related articles

This study examined cortical lesions in progressive supranuclear palsy (PSP). Findings suggest distinct tau pathology patterns in PSP brains, differing from Alzheimer's disease.

Area of Science:

Neuropathology
Neurodegenerative Diseases

Background:

Progressive supranuclear palsy (PSP) is a tauopathy with poorly understood cortical pathology.
Distinguishing PSP from other neurodegenerative diseases like Alzheimer's disease (AD) is crucial for diagnosis and treatment.

Purpose of the Study:

To investigate the distribution and characteristics of neocortical and hippocampal lesions in PSP.
To compare the neuropathological findings in PSP with those in Alzheimer's disease.

Main Methods:

Examined ten PSP and five Alzheimer's disease cases.
Utilized Bodian's stain, tau, ubiquitin, and beta-amyloid (beta A4) immunocytochemistry on ten cortical areas.
Analyzed the density and laminar distribution of neurofibrillary tangles.

Related Experiment Videos

Main Results:

All PSP cases exhibited neocortical tangles, fiber tufts, and neuropil threads, stained by tau but not ubiquitin.
Amyloid plaques and deposits were rare in PSP, unlike in Alzheimer's disease.
Tangle density was highest in cortical area 4, with a specific laminar distribution (layers V-VI) in PSP, contrasting with the bimodal distribution in Alzheimer's disease.

Conclusions:

Cortical alterations in PSP, particularly tau pathology, show distinct patterns compared to Alzheimer's disease.
These findings support the specificity of neuropathological changes in the cortex in progressive supranuclear palsy.