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Related Experiment Videos

Motoneuron plasticity underlying operantly conditioned decrease in primate H-reflex

J S Carp1, J R Wolpaw

  • 1Wadsworth Center for Laboratories and Research, New York State Department of Health, Albany.

Journal of Neurophysiology
|July 1, 1994
PubMed
Summary
This summary is machine-generated.

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Operant conditioning modifies spinal cord plasticity in monkeys, altering triceps surae motoneuron firing thresholds and conduction velocity. This spinal cord adaptation explains behavioral changes in the H-reflex size.

Area of Science:

  • Neuroscience
  • Motor Control
  • Spinal Cord Plasticity

Background:

  • The triceps surae H-reflex in monkeys can be modulated through operant conditioning, indicating spinal cord plasticity.
  • Understanding the neural mechanisms underlying this adaptation is crucial for explaining behavioral changes in H-reflex size.

Purpose of the Study:

  • To investigate the location and nature of spinal cord plasticity during H-reflex conditioning.
  • To determine the role of this plasticity in the observed behavioral changes (H-reflex increase or decrease).

Main Methods:

  • Intracellular recordings were performed on triceps surae motoneurons in monkeys undergoing operant conditioning (HRdown task).
  • Data from conditioned animals (successful and unsuccessful) were compared with data from naive (unconditioned) animals.

Related Experiment Videos

  • Measurements included axonal conduction velocity, firing threshold, and postsynaptic potentials.

    • Main Results:

    • Successful HRdown conditioning in monkeys led to a more positive average firing threshold in motoneurons on the trained side compared to naive animals.
    • A significantly lower average axonal conduction velocity was observed in motoneurons from successful HRdown animals.
    • Motoneurons from unsuccessful conditioned animals did not show significant differences from naive animals.

    Conclusions:

    • Operant conditioning-induced decrease in H-reflex size is associated with a positive shift in motoneuron firing threshold.
    • This shift necessitates greater depolarization to reach the firing threshold, explaining the behavioral change.
    • The altered firing threshold may also account for the observed decrease in axonal conduction velocity.