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Somatomedin C (insulin-like growth factor 1) levels decrease during acute changes of stress related hormones.
G Ferraccioli1, P Guerra, V Rizzi
1Institute of Internal Medicine, Chair of Clinical Pharmacology, School of Medicine, Udine, Italy.
The Journal of Rheumatology
|July 1, 1994
Summary
Stress hormones like cortisol and norepinephrine (NE) can lower insulin-like growth factor 1 (IGF-1) levels. This study investigated the acute effects of these hormones on IGF-1 regulation.
Area of Science:
- Endocrinology
- Metabolic Research
- Neuroendocrinology
Background:
- Insulin-like growth factor 1 (IGF-1) plays a crucial role in growth and metabolism.
- Stress hormones, including cortisol and norepinephrine (NE), are known to influence various physiological processes.
- The direct impact of acute stress hormone release on IGF-1 levels requires further elucidation.
Purpose of the Study:
- To investigate the acute effects of stress hormones on insulin-like growth factor 1 (IGF-1) levels.
- To determine the specific roles of cortisol and norepinephrine in modulating IGF-1 during acute stress.
Main Methods:
- Induction of insulin-induced hypoglycemia (< 3 mmol/l) to stimulate stress hormone release.
- Administration of clonidine to depress noradrenergic tone and isolate the effects of NE.
- Measurement of cortisol, human growth hormone (hGH), norepinephrine (NE), and IGF-1 levels.
Main Results:
- Hypoglycemia led to increased hGH, cortisol, and NE, but a statistically significant decrease in IGF-1.
- Even when NE tone was suppressed by clonidine, a significant decrease in IGF-1 was observed.
- These findings suggest a direct inhibitory effect of acute cortisol release or NE reduction on IGF-1.
Conclusions:
- Acute release of cortisol is associated with reduced IGF-1 levels.
- A decrease in norepinephrine tone also contributes to lower IGF-1 concentrations.
- These hormonal changes during acute stress impact IGF-1 regulation.