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The sulfonamide-diaminopyrimidine story
1Department of Veterinary Basic Sciences, Utrecht University, The Netherlands.
Journal of Veterinary Pharmacology and Therapeutics
|August 1, 1994
Summary
Chemotherapy, using selective toxicity principles, led to the development of sulfonamides and diaminopyrimidines. These antimicrobial agents, like trimethoprim-sulfadiazine, remain vital in veterinary medicine today.
Area of Science:
- * Pharmacology and Medicinal Chemistry
- * Antimicrobial Drug Development
Background:
- * The concept of chemotherapy, defined as selective toxicity for treating infectious diseases, was pioneered by Paul Ehrlich.
- * Gerhard Domagk's work on Prontosil rubrum, a precursor to sulfanilamide, demonstrated the in vivo efficacy of chemical agents.
- * Sulfanilamide's discovery spurred extensive research, leading to over 5400 derivatives and related drug classes like diuretics and antidiabetogenic agents.