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Similar activity of chlorambucil and its spermidine conjugate in the mouse bone marrow micronucleus assay
Mutagenesis
|July 1, 1994
Abstract:
The spermidine conjugate of the human carcinogen and cancer therapeutic agent chlorambucil has been evaluated in the mouse bone marrow micronucleus assay. It showed a similar level of activity to that of chlorambucil, indicating that the superior ability of the conjugate to cross-link DNA in vitro is not expressed as enhanced genotoxicity in vivo.