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Isoflurane inhibits calcium currents in neocortical neurons
E Puil1, B Hutcheon, P B Reiner
1Department of Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
Neuroscience Letters
|July 18, 1994
Abstract:
We used voltage-clamp techniques to assess the effects of isoflurane anaesthesia in slices of sensorimotor cortex of guinea pigs and neonatal rats. Isoflurane (0.5-4%) depressed inward Ca(2+)-currents evoked by depolarizing commands from -50 mV. With additional blockade of K(+)-currents by internal Cs+, an early component of the sustained inward currents was a high voltage-activated current whereas the delayed component was an unclamped Ca(2+)-current; this was consistent with a simple compartmental model. Isoflurane decreased the magnitude of the high voltage-activated current.