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Knemometry

C MacKenzie1

  • 1Sheffield Children's Hospital, U.K.

Respiratory Medicine
|August 1, 1994
PubMed
Summary
This summary is machine-generated.

Monitoring children

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Area of Science:

  • Pediatric Endocrinology
  • Growth Monitoring
  • Pharmacology

Background:

  • Knemometry is valuable for assessing short-term growth patterns.
  • The long-term effects of corticosteroid-induced growth suppression are not fully understood.
  • Oral and inhaled corticosteroids can suppress lower leg growth.

Purpose of the Study:

  • To clarify the long-term clinical implications of growth suppression from inhaled corticosteroids.
  • To evaluate the evidence for biochemical and clinical effects of specific inhaled corticosteroids.

Main Methods:

  • Review of accumulating evidence on inhaled corticosteroid effects.
  • Analysis of growth patterns using knemometry.
  • Assessment of biochemical and clinical markers.

Main Results:

  • Evidence suggests measurable effects from beclomethasone dipropionate and budesonide at higher doses.
  • Short-term non-response to growth therapies predicts poor long-term outcomes.
  • Inhaled corticosteroids may have significant long-term impacts on growth.

Conclusions:

  • Careful growth monitoring is essential for children using inhaled corticosteroids.
  • The lowest effective dose of inhaled corticosteroids should be used to minimize growth suppression.
  • Further research is needed to fully elucidate long-term implications.

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