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Antimycobacterial drugs
1Mycobacteriology Laboratory, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206.
Seminars in Respiratory Infections
|June 1, 1994
Summary
This review details antimycobacterial drugs for tuberculosis, Mycobacterium avium complex, and M. fortuitum/chelonae infections. It covers drug selection, in vitro activity, and susceptibility testing for optimal treatment regimens.
Area of Science:
- Microbiology
- Pharmacology
- Infectious Diseases
Background:
- Antimycobacterial drug selection is crucial for treating diverse mycobacterial infections.
- Understanding drug activity and susceptibility is key to effective therapeutic strategies.
Purpose of the Study:
- To provide a comprehensive overview of antimycobacterial agents.
- To guide drug selection, evaluate in vitro antimicrobial activity, and interpret susceptibility testing.
Main Methods:
- Review of general principles for selecting antimycobacterial drugs.
- Analysis of in vitro antimicrobial activity, including inhibitory and bactericidal potency.
- Examination of drug susceptibility testing methodologies and interpretation.
Main Results:
- Detailed examination of drugs against tuberculosis, Mycobacterium avium complex, and M. fortuitum/chelonae.
- Assessment of various drug classes including antibiotics, antimicrobials, and other agents.
- Discussion of susceptibility testing for guiding treatment decisions.
Conclusions:
- Effective management of mycobacterial infections relies on informed drug selection and susceptibility testing.
- This review offers critical insights into the efficacy and application of numerous antimycobacterial agents.