[Centralized preparations of cytostatic agents: a method for quality control]

Cytotoxic drugs are frequently used in a hospital setting. They are mainly administered intravenously and require reconstitution and preparation of the solutions. This is commonly done by nurses in the nursing station. However, cytotoxic drugs are potentially hazardous to personnel and patients, and appropriate waste disposal is necessary. Centralized preparation of cytotoxic medication reduces these risks and problems. We review our experience with centralized preparation and controlled application of chemotherapy in a major medical center. It improves overall safety in reducing exposure to the drugs, while errors of dosage and handling can be decreased and costs and volume of hazardous waste are lower to a substantial extent. Central preparation of cytotoxic drugs is feasible and allows improved quality control.