Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Decrease in the corticosterone content in rat blood after intraperitoneal or per os administration of histones]

V I Tiulenev, G V Tiuleneva

    Ukrainskii Biokhimicheskii Zhurnal (1978)
    |January 1, 1994
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Inhibition of proteolysis of nuclear histones by metal ions].

    Ukrains'kyi biokhimichnyi zhurnal (1999 )·2000
    Same author

    [Effect of urea on proteolysis of histone H2A in calf thymus nuclei].

    Ukrains'kyi biokhimichnyi zhurnal (1999 )·1999
    Same author

    [Inhibition of nuclear histone proteolysis by nucleotides].

    Ukrainskii biokhimicheskii zhurnal (1978)·1999
    Same author

    [Effect of adenosine triphosphate on the cleavage of H1 histones in nuclei of rat spleen and liver].

    Ukrainskii biokhimicheskii zhurnal (1978)·1996
    Same author

    [Role of S-100 protein in the function of brain cell nuclei].

    Ukrainskii biokhimicheskii zhurnal (1978)·1996
    Same author

    [Increase in thyroxine level in blood plasma of hypothyroid rats after administering histones].

    Ukrainskii biokhimicheskii zhurnal (1978)·1995

    Histone injections significantly decrease corticosterone levels in rats, with effects varying by dose and time. Pronase E and albumin, however, increase corticosterone levels.

    Area of Science:

    • Biochemistry
    • Endocrinology
    • Pharmacology

    Context:

    • The study investigates the physiological effects of various proteins on blood corticosterone levels in rats.
    • Corticosterone is a key stress hormone regulated by complex biological pathways.

    Purpose:

    • To determine the influence of histones, protamine, pronase E, and albumin on rat blood corticosterone concentrations.
    • To elucidate the dose-dependent and time-dependent effects of these substances.

    Summary:

    • Histone injections (10-500 mcg/100g) led to a dose- and time-dependent decrease in blood corticosterone, with a 96% reduction observed at 5 hours post-500 mcg injection.
    • Digestion of histones with pronase E altered their effect, with intensive digestion leading to an increase in corticosterone levels.
    • Protamine injection showed no immediate effect but increased corticosterone at 48 hours, while pronase E and albumin increased corticosterone levels.

    Related Experiment Videos

    Impact:

    • Findings suggest histones play a regulatory role in the hypothalamic-pituitary-adrenal (HPA) axis.
    • Understanding these interactions could offer new insights into stress hormone modulation and potential therapeutic targets.