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The basis for common reference intervals for serum potassium

M S Djurhuus1, P H Petersen, A Rohold

  • 1Department of Clinical Chemistry, Odense University Hospital, Denmark.

Upsala Journal of Medical Sciences
|January 1, 1993
PubMed
Summary
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This study found that analytical bias in S-Potassium measurements across Danish hospitals is within acceptable limits. This suggests that uniform potassium reference intervals are feasible if preanalytical errors are managed.

Area of Science:

  • Clinical Chemistry
  • Laboratory Medicine
  • Analytical Toxicology

Background:

  • The lower reference limit for serum potassium (S-Potassium) in Danish hospitals is currently in use.
  • Investigating the relevance of this limit is crucial for accurate patient diagnosis and treatment.

Purpose of the Study:

  • To compare the analytical bias in S-Potassium measurements with the established lower reference limit across 52 Danish hospital laboratories.
  • To determine the acceptability of the observed analytical bias in relation to established criteria.

Main Methods:

  • Analytical bias for S-Potassium was assessed in 52 Danish hospital laboratories.
  • The acceptable bias range was estimated using the Gowans et al. method with two reference sample groups.
  • Observed bias was compared against the estimated acceptable bias range.

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Main Results:

  • The estimated acceptable 0.95 bias range for S-Potassium was 0.24 mmol/L.
  • The observed bias range across the laboratories was 0.23 mmol/L, falling within the acceptable limit.
  • Preanalytical errors were noted to consistently increase measured S-Potassium values.

Conclusions:

  • The analytical performance of S-Potassium measurements in Danish hospitals is adequate.
  • Uniform or common reference intervals for S-Potassium are achievable across Danish and potentially Nordic hospital laboratories.
  • Effective control of preanalytical errors is essential for implementing uniform reference intervals.