Seizures and other neurologic manifestations of allergy

Numerous disease entities affecting the nervous system can be attributed at least in part to immune responses. Neurons have been shown to have receptors from many of the vasoactive neurotransmitter and neuromodulator molecules first studied as mediators of inflammation and immediate hypersensitivity (Type 1 response). Immune responses have now been proven to affect CNS and peripheral neurons. In the diagnostic workup, consideration should be given to the possibility of immune-related causes for seizures and some other neurologic disorders.