The relationship of anticipatory smooth eye movement to smooth pursuit initiation

We measured anticipatory smooth eye movements and smooth pursuit initiation with predictable and unpredictable step-ramp stimuli in normal subjects. Subjects generated anticipatory eye motion before targets moved and during intervals when targets suddenly disappeared. Expectations of target trajectory modified pursuit acceleration and latency, demonstrating that pursuit initiation is not governed by visual inputs alone. Anticipatory smooth eye movements and predictive contributions to smooth pursuit had similar accelerations and velocities. Anticipation and pursuit initiation varied in parallel between subjects; anticipation was stronger in subjects who generated faster smooth pursuit. These findings imply that anticipatory and smooth pursuit eye movements are governed by a common mechanism.