Related Experiment Video
Updated: Aug 13, 2026

Pseudofracture: An Acute Peripheral Tissue Trauma Model
Published on: April 18, 2011
[Nuclease activity in multiple trauma]
Abstract:
Activities of acid and alkaline DNAses and RNAses as well as content of insulin were studied in blood of patients with severe mechanical trauma. Distinct alterations in activities of acid and alkaline DNAses were observed in the acute period of the disease and the activity was normalized within 14-21 days. The RNAase system exhibited the most pronounced response to the trauma, while activity of acid RNAase exceeded the normal level by 52% within 21 days of the posttraumatic period. Activities of acid and alkaline RNAases were increased simultaneously with elevation of the insulin content in blood within 14-21 days of the disease. Thus, alterations in the nucleases activity proved to be a sensitive response of a body to mechanical trauma.
Related Concept Videos
Nucleotide Excision Repair
Nucleotide Excision Repair
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
Phases of Wound Repair
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Cellular Injury IV: Necrosis
Acute Inflammation III: Local and Systemic Effects

