Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A new low-frequency red cell antigen, 'SARAH'

D A Stern1, D N Hawksworth, J M Watt

  • 1National Blood Group Reference Laboratory, CSL Ltd., Parkville, Vic., Australia.

Vox Sanguinis
|January 1, 1994
PubMed
Summary

Researchers identified a new low-frequency antigen (LFA), SARAH, through family studies and advanced testing. This discovery led to its provisional designation as ISBT number 700.052, expanding the known blood group antigen catalog.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cough during infancy and subsequent childhood asthma.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2015
Same author

Air lead concentrations in Birmingham, England - a comparison between levels inside and outside inner-city homes.

Environmental geochemistry and health·2013
Same author

Lead contamination of UK dusts and soils and implications for childhood exposure: An overview of the work of the Environmental Geochemistry Research Group, Imperial College, London, England 1981-1992.

Environmental geochemistry and health·2013
Same author

Relation of early antibiotic use to childhood asthma: confounding by indication?

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2010
Same author

Decreased activation of inflammatory networks during acute asthma exacerbations is associated with chronic airflow obstruction.

Mucosal immunology·2010
Same author

Propofol sedation for oesophago-gastro-duodenoscopy.

Diagnostic and therapeutic endoscopy·2008

Area of Science:

  • Immunogenetics
  • Blood group serology

Background:

  • Over 100 low-frequency antigens (LFAs) are cataloged by the International Society of Blood Transfusion (ISBT).
  • Unpublished LFAs are known within reference laboratories, posing challenges in blood transfusion compatibility.

Observation:

  • Two sera reacted with a single K homozygous cell sample, suggesting a novel antigen.
  • Standard testing against known LFAs and sera failed to identify the antibody specificity.
  • Inheritance of the antigen was observed across two generations in the donor's family.

Findings:

  • Extensive testing, including immunoblotting and RFLPs, was conducted internationally.
  • All previously published LFAs were excluded as potential specificities.
  • The novel antigen, SARAH, was identified and excluded from known LFAs.

Related Experiment Videos

Implications:

  • The SARAH antigen was provisionally assigned the ISBT number 700.052.
  • This discovery expands the known repertoire of blood group antigens.
  • Accurate identification of LFAs like SARAH is crucial for preventing alloimmunization and ensuring transfusion safety.