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CSF dynamics in patients with meningiomas
1Burdenko Neurosurgery Institute, Moscow, Russia.
Acta Neurochirurgica. Supplementum
|January 1, 1994
Summary
This study found that increased brain swelling (BE) volume correlates with altered cerebrospinal fluid (CSF) dynamics and brain elasticity in patients with brain tumors. Higher BE volumes are linked to increased CSF flow and resistance, indicating potential compression effects.
Area of Science:
- Neurosurgery
- Neurology
- Radiology
Background:
- Peritumoral brain edema (BE) is a common complication of brain tumors, affecting intracranial pressure and fluid dynamics.
- Understanding cerebrospinal fluid (CSF) dynamics and brain elasticity is crucial for managing patients with brain tumors and associated edema.
Purpose of the Study:
- To investigate the relationship between peritumoral brain edema (BE) volume and cerebrospinal fluid (CSF) dynamics.
- To assess brain elasticity in patients with supratentorial meningiomas and peritumoral BE.
Main Methods:
- Planimetric volume determination of tumor and BE on CT scans.
- Evaluation of CSF dynamics using constant-pressure infusion-drainage tests.
- Correlation analysis between tumor volume (Vt), BE volume (Ve), CSF outflow resistance (R), and CSF flow (F).
Main Results:
- A significant positive correlation was found between BE volume (Ve) and CSF flow (F).
- Increased CSF flow (F) in patients with high BE volumes may be attributed to BE fluid clearance and CSF production.
- Elevated CSF outflow resistance (R) correlated with maximum tumor (Vt) and BE (Ve) volumes, suggesting compression of arachnoid villi.
Conclusions:
- Peritumoral BE significantly impacts CSF dynamics and brain elasticity.
- Increased BE volume is associated with altered CSF flow and resistance, likely due to mechanical compression.
- These findings highlight the importance of considering BE in the management of intracranial pressure in brain tumor patients.