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Metabolic changes following cortical contusion: relationships to edema and morphological changes
R L Sutton1, D A Hovda, P D Adelson
1Division of Neurosurgery, University of New Mexico, Albuquerque.
Acta Neurochirurgica. Supplementum
|January 1, 1994
Abstract:
Rats with contusion injury to the right cortex exhibited significant formation of edema 6 and 24 hours after injury which resolved by 8 days and was replaced by cavitation necrosis. The contusions produced hyperglycolysis and ischemia in the impacted cortical tissue and underlying hippocampus immediately through 30 minutes post-injury. Glucose utilization was depressed throughout the contused cortex and in ipsilateral subcortical regions, as was blood flow, at chronic (1 and 10 days) periods after injury.